Animal models of neurodegenerative diseases
نویسندگان
چکیده
منابع مشابه
Animal models of neurodegenerative diseases.
The prevalence of neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), increases with age, and the number of affected patients is expected to increase worldwide in the next decades. Accurately understanding the etiopathogenic mechanisms of these diseases is a crucial step for developing disease-modifying drugs able to preclude their emergence or at least sl...
متن کاملAnimal models in neurodegenerative diseases.
Ideally, animal models of neurodegenerative diseases should reproduce the clinical manifestation of the disease and a selective neuronal loss. In this review we will take as an example Parkinson's disease because its pathophysiology is well known and the neuronal loss well characterized. Indeed, Parkinson's disease is characterized by a loss of some but not all dopaminergic neurons, a loss of s...
متن کاملNon-Clinical Models for Neurodegenerative Diseases: Therapeutic Approach and Drug Validation in Animal Models
In 2016, 19.8% of the Cuban population was aged 60 or over. As a result, age-associated degenerative diseases and other diseases have become priority targets from a prophylactic, diagnostic and therapeutic perspective. As a result, the Cuban biomedical scientific community has addressed its basic, preclinical and epidemiological research in order to rise up to the challenge. A firm step in this...
متن کاملMRS in mouse models of neurodegenerative diseases
Enormous progress has been made in the last decade towards elucidating the pathogenesis of human neurodegenerative diseases. The successful characterization of pathogenic mutations in several inherited diseases together with genetic engineering enabled the creation of transgenic and knock-in mouse models of human neurodegenerative diseases, such as Huntington's disease (HD), spinocerebellar ata...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2018
ISSN: 1097-6256,1546-1726
DOI: 10.1038/s41593-018-0236-8